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. 2017 Oct 13;26(1):6–15. doi: 10.1016/j.tim.2017.09.007

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© 2017 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Key Figure: Basic Epidemiological Properties of Transmissible Vaccines

Each row represents a population at a point in time. Time flows down. Gray circles are individuals with the vaccine, open circles are susceptible. Arrows represent transmission of the vaccine from one individual to another. Directly vaccinated individuals are those with no arrow leading into them. (A) A weakly transmissible vaccine. Direct vaccination occurs in the first time interval shown, and the vaccine quickly dies out. (B) A highly transmissible vaccine; the vaccine spreads. (C) A weakly transmissible vaccine in which direct vaccination continues throughout the time shown. Although chains of transmission are short, they increase the number of vaccinated individuals within the population.