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. 2017 Dec 12;15(2):2661–2668. doi: 10.3892/ol.2017.7591

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Figure 4. — MAPK signal pathway involved in CRLS1 co-expression genes by KEGG pathway analysis. (A) JNK/c-JUN MAPK signaling pathway. (B) p38 MAPK signaling pathway. (C) ERK MAPK signaling pathway. Arrows indicate promotion. T-shaped arrows represent an inhibitory effect. Genes in brackets represent CRLS1 co-expression genes. +p, phosphorylation; -p, dephosphorylation; CRLS1, cardiolipin synthase 1; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase; JNK, c-Jun N-terminal kinase; ERK, extracellular signal-regulated kinase; TNF, tumor necrosis factor; IL1, interleukin 1; TNFR, TNF receptor; CASP, caspase; TRAF2, TNFR-associated factor 2; MEKK1, MAPK kinase kinase kinase 1; HPK1, hematopoietic progenitor kinase 1; MLK3, mixed lineage kinase 3; MKK, MPAK kinase.

Figure 4. — MAPK signal pathway involved in CRLS1 co-expression genes by KEGG pathway analysis. (A) JNK/c-JUN MAPK signaling pathway. (B) p38 MAPK signaling pathway. (C) ERK MAPK signaling pathway. Arrows indicate promotion. T-shaped arrows represent an inhibitory effect. Genes in brackets represent CRLS1 co-expression genes. +p, phosphorylation; -p, dephosphorylation; CRLS1, cardiolipin synthase 1; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase; JNK, c-Jun N-terminal kinase; ERK, extracellular signal-regulated kinase; TNF, tumor necrosis factor; IL1, interleukin 1; TNFR, TNF receptor; CASP, caspase; TRAF2, TNFR-associated factor 2; MEKK1, MAPK kinase kinase kinase 1; HPK1, hematopoietic progenitor kinase 1; MLK3, mixed lineage kinase 3; MKK, MPAK kinase.