Table 2.

Univariate and Multivariate Analyses of Risk Factors Associated with Hepatocellular Carcinoma Recurrence after Orthotopic Liver Transplantation

Variable	Univariate			Multivariate
	HR	95% CI	p Value	HR	95% CI	p Value
Age, y, ≤58 vs >58	1.08	0.73 to 1.56	0.745
Sex, male vs female	1.48	0.89 to 2.50	0.129
Race, non-Caucasian vs Caucasian	0.89	0.46 to 1.69	0.703
BMI, kg/m2, ≤28 vs >28	0.86	0.59 to 1.25	0.433
AFP before OLT, ng/mL (≤500 vs >500)	1.46	0.67 to 3.12	0.342
Etiology, non-viral vs viral	1.29	0.84 to 1.98	0.255
LRT, no vs yes	1.02	0.69 to 1.49	0.933
LRT, single vs multiple	0.84	0.48 to 1.47	0.560
MELD score, ≤20 vs >20	1.45	0.88 to 2.38	0.142
Explanted tumor
No. of tumors, ≤3 vs >3	5.94	2.44 to 14.4	0.001	3.26	1.28 to 8.27	0.031
Tumor size, ≤3 cm vs >3 cm	3.15	1.56 to 6.37	0.001	1.99	0.96 to 4.16	0.043
Macrovascular invasion, no vs yes	7.95	3.24 to 19.4	0.006	4.56	1.64 to 12.7	0.004
Microscopic LVSI, no vs yes	3.64	1.72 to 7.68	0.001	2.49	1.08 to 5.78	0.032
Non-partial necrosis vs partialnecrosis	5.21	2.41 to 11.3	0.001	4.79	2.19 to 10.5	0.001

Cox regression model, p<0.05 was considered significant.

AFP, alpha-fetoprotein; HR, hazard ratio; LRT, locoregional therapy; MELD, Model for End-Stage Liver Disease; OLT, orthotopic liver transplantation