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. 2018 Jan 4;8:958. doi: 10.3389/fphar.2017.00958

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Copyright © 2018 Corbet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Manipulating pyruvate metabolism in stem cells. (A) Small molecules targeting either reductive or oxidative metabolism of pyruvate can be used to rewire stem cell metabolism. (B) Blockade of pyruvate oxidative metabolism may impair cell differentiation while promoting stem cell activation toward either expansion, maintenance or commitment. 2-DG, 2-deoxyglucose; 3-BrPA, 3-bromopyruvate; DCA, dichloroacetate.