Table 2. Intra- and intergroup comparisons of clinical and microbiological parameters (mean ± SD or median, IQ score).
| Probiotic group | Antibiotic group | Placebo group | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (n=16) | (n=16) | (n=15) | |||||||||||||
| Baseline | 3 months | 6 months | 9 months | P | Baseline | 3 months | 6 months | 9 months | P | Baseline | 3 months | 6 months | 9 months | P | |
| CAL (mm) | 3.8 ± 0.7 | 3.4±0.6† | 3.3 ±0.6 | 3.4±0.6† | 0.0001* | 4.4 ±0.9 | 4.0 ± 1.0† | 3.9 ± 1.0† | 4.1 ±1.0 | 0.0001* | 4.7 ± 1.5 | 4.1 ± 1.4† | 4.1 ± 1.4† | 4.3 ± 1,4† | 0.0001* |
| PPD (mm) | 2.7 ± 0.6 | 2.1 ±0.3† | 2.3 ± 0.4† | 2.2±0.3† | 0.0001* | 2.9 ±0.4 | 2.3 ± 0.4† | 2.3 ± 0.3† | 2.3 ± 0.3† | 0.0004* | 3.1 ± 0.9 | 2.4±0.5† | 2.4±0.5† | 2.5 ± 0.6† | 0.0001* |
| BOP(%) | 49.3 ± 18.1 | 39.2 ± 14.8 | 42.1 ± 13.6 | 42.4 ± 14.6 | 0.0010* | 57.4 ± 10.2 | 43.6 ± 12.5† | 44.1 ± 13.5† | 48.1 ± 14.1 | 0.0128* | 52.5 ± 12.6 | 40.7 ± 13.3† | 41.5 ± 14.5† | 45.9 ± 12.9 | 0.0002* |
| Plaque accumulation (%) | 54.5 ± 18.8 | 24.7 ± 11.3† | 25.2 ± 13.1† | 28.1 ± 14.6† | 0.0023* | 58.6 ± 18.8 | 28.0 ± 17.5† | 32.6 ± 15.7† | 31.8 ± 14.8† | 0.0001* | 56.1 ± 9.4 | 32.4 ± 13.9† | 28.7 ± 13.0† | 27.4 ± 13.0† | 0.0119* |
| Total cultivable microbiota (CFU)* 105 | 7.6, 31.8 | 0.5, 1.3 | 0.8, 1.7† | 0.6, 2.9 | 0,0619 | 10.2, 23.5 | 1.1,3.0† | 1.9, 4.0† | 2.2, 5.9† | 0,0937 | 10.0, 20.2 | 2.9, 25.4 | 0.5, 8.1 | 2.8, 24.7 | 0,1445 |
Intra-group comparison by
*
Friedman test (p<0.05) and intra- group multiple comparison by
†
Bonferroni- corrected Wilcoxon signed rank test (p<0.017). Significant values were given in bold formatting.
Inter-group multiple comparison by
**
Bonferroni- corrected Kruskal Wallis test and ANOVA (p<0.017)
CAL: Clinical attachment level; PPD: Probing pocket depth; BOP: Bleeding on probing; CFU: Colony forming units