Table 1.
Characteristics of cases
| SJS | SJS/TEN overlap | TEN | Total | |||||
|---|---|---|---|---|---|---|---|---|
| 51 | 14 | 47 | 112 | |||||
| Typical | Atypical | Typical | Atypical | Typical | Atypical | Typical | Atypical | |
| 41 | 10 | 12 | 2 | 46 | 1 | 99 | 13 | |
| Male/female | 27/24 | 7/7 | 17/30 | 51/61 | ||||
| Age | ||||||||
| <18 years | 11 | 0 | 1 | 0 | 11 | 0 | 23 | 0 |
| ≥18 years | 30 | 10 | 11 | 2 | 35 | 1 | 76 | 13 |
| Age (years) | ||||||||
| Mean ± SD | 36.9 ± 21 | 43.9 ± 18.9 | 43.1 ± 27.9 | 40.5 ± 24.4 | ||||
| Median (range) | 33 (6–77) | 37 (25–83) | 44 (1–90) | 37 (1–90) | ||||
| IQR: 1–3 | 19–56 | 30–46 | 18.5–67.5 | 19.8–61.3 | ||||
| Death | 1 | 1 | 14 | 16 | ||||
| Allocation according to ALDEN score for acetaminophen vs. other suspect drugs | ||||||||
| Group 1 | 27 | 7 | 7 | 2 | 28 | 1 | 62 | 10 |
| Group 2 | 3 | 1 | 2 | 0 | 2 | 0 | 7 | 1 |
| Group 3 | 11 | 2 | 3 | 0 | 16 | 0 | 30 | 2 |
ALDEN, algorithm of drug causality for epidermal necrolysis; IQR, interquartile range; SD, standard deviation; SJS, Stevens–Johnson syndrome; TEN, toxic epidermal necrolysis
Group 1: ALDEN score for acetaminophen less than that for all other suspect drugs
Group 2: ALDEN score for acetaminophen equal to that for at least one other suspect drug
Group 3: ALDEN score for acetaminophen greater than that for all other suspect drugs, or acetaminophen being the only suspect drug