Table 3.
Descriptive summary of plasma PF‐06273340 pharmacokinetic parameter values
| Parameter (units) | Parameter summary statistics a by PF‐06273340 treatment | |
|---|---|---|
| 50 mg | 400 mg | |
| N | 19 | 19 |
| AUC last (ng•h ml –1 ) | 483.5 (42) | 3630 (43) |
| C max (ng ml –1 ) | 150.4 (57) | 1396 (56) |
| T max (h) | 1.08 (1.00–3.00) | 1.00 (0.500–2.00) |
AUClast, area under the plasma concentration–time curve from time 0 to the time of last quantifiable concentration; Cmax, maximum observed plasma concentration; %CV, percentage coefficient of variation; Tmax, time to reach Cmax
a
Geometric mean (geometric %CV) for all except: median (range) for Tmax.