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Transmembrane nanotube (TM) length increases with dismal prognosis*61
| WHO Grade | WHO Grade II Astrocytoma | WHO Grade III Astrocytoma |
WHO Grade IV
Astrocytoma (Glioblastoma) |
|---|---|---|---|
| <50 µm [%] | 10–20 | <10 | <10 |
| 50–100 µm [%] | >50 | >50 | 30–40 |
| >100 µm [%] | 20–30 | 30–40 | >50 |
*Glioma thick sections stained positive for the IDH1 R132H protein have been analyzed for the prevalence of TM in different length. Parallel experiments had revealed that TM length is correlated with therapy resistance.
