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. Author manuscript; available in PMC: 2018 Jan 22.
Published in final edited form as: Dev Neurobiol. 2017 Jul 25;77(10):1221–1236. doi: 10.1002/dneu.22512

Figure 4.

Figure 4

Impact of neonatal infection on proinflammatory gene expression in the spleen, a peripheral immune organ, of juvenile male and female rats following a mild immune challenge of LPS (25 μg/kg). (A) Relative gene expression of the proinflammatory cytokine IL-1β from the spleen. (B) Relative gene expression of the proinflammatory cytokine IL-6 from the spleen. Error bars represent ± SEM. *P < 0.05 indicates the main effect of LPS causing increased IL-1β and increased IL-6 expression in male and female rats regardless of neonatal infection status. †P < 0.0001 indicates post hoc tests following significant Sex × Neonatal Treatment × P24 Treatment interaction showing the effect of neonatal infection further attenuating IL-6 expression following LPS in juvenile males.