Table 1.

Key Studies Assessing the Utility of Allergy Testing in EoE

Study (year)	Testing Modality	# of Subjects	Histologic Response	Additional Findings
Children
Spergel et al (2002)31	SPT and APT	26	75%*	Prospective study Milk and egg were the most common positive foods by SPT Wheat was the most common positive food by APT
Spergel et al (2005)53	SPT and APT	146	49%§	Retrospective analysis of clinic population Egg, milk, and soy were most common trigger foods identified by SPT Corn, soy, and wheat were most common foods identified by APT
Spergel et al (2012)32	SPT and APT	319	53%§	Retrospective analysis of clinic population Of 941 patients, causative foods were identified in 319 Similar histologic success for SPT/APT directed diets and SFED Most common trigger foods were milk, egg, wheat, and soy
Al-Hussaini et al (2013)102	SPT and Food-specific IgE (ImmunoCAP >0.35 kU/L)	10	40%**	Prospective study Most common trigger foods were milk, soy, wheat, egg, and nuts
Henderson et al (2012)54	SPT and APT	23	65%**	Retrospective comparison of elemental, SFED, and allergy-testing directed diets Elemental diet was the most effective. SFED and allergy-testing directed diets had comparable effectiveness
Adults
Molina-Infante et al (2012)55	SPT, APT, and prick-prick testing	15	33%†	Prospective trial Foods that were positive by any form of testing were eliminated
Wolf et al (2014)103	SPT	22	32%*	Retrospective study of clinic cohort Milk, egg, and wheat were most common trigger foods
Rodriguez-Sanchez et al (2014)56	Food-specific IgE (ImmunoCAP >0.1 kU/L)	26	73%†	Compared SFED to sIgE-targeted diets. Fewer foods were removed and fewer EGDs were required in sIgE-directed diet. Most common triggers: milk, wheat, egg, and legumes
Van Rhijn et al (2015)104	Component IgE (ISAC microchip)	15	7%‡	Prospective trial of IgE-directed diet, based on ISAC assay. Trial was prematurely terminated because only 1/15 patients showed improvement in the interim analysis.

SPT = Skin prick testing; APT = Atopy Patch Testing;

^*Based on resolution of symptoms and biopsy results when available;

^§< 5 eosinophils/hpf;

^**< 15 eosinophils/hpf;

^†<14 eosinophils/hpf and clinical improvement;

^‡<10 eosinophils/hpf