Table 2.

Key studies assessing utility of empiric diets in EoE

Study (year)	Empiric Diet	# of Subjects	Histologic Response	Additional Findings
Children
Kagalwalla et al (2006)70	Six-food elimination	35	74%‡	Retrospective observational study comparing SFED with elemental formula diet. Established that the SFED is associated with clinical and histologic improvement in EoE
Henderson et al (2012)54		26	81%*	Retrospective comparison of elemental, SFED, and allergy-testing directed diets, as outlined in Table 1
Kagalwalla et al (2017)74	Four-food elimination	78	64%	Prospective observational study Patients with detectable specific IgE (>0.35 IU/mL) were less likely to respond to diet
Kagalwalla et al (2012)105	Milk only	17	65%*	Retrospective study of clinic cohort
Erwin et al (2016)57		21	62%*	Prospective observational study Demonstrated that patients with low, and even undetectable, specific IgE to milk responded to milk elimination diet.
Adults
Gonsalves et al (2012)72	Six-food elimination	50	74%*	First study of SFED in adults. Most common triggers: wheat and milk SPT only predicted trigger foods in 13%
Lucendo et al (2013)76		67	73%*	Also excluded rice, corn, and legumes 15 patients demonstrated remission at 2y Most common triggers: milk, wheat, eggs, and legumes
Rodriguez-Sanchez et al (2014)56		17	53%*	Compared SFED to sIgE-targeted diets, as outlined in Table 1
Philpott et al (2016)69		56	52%*	Prospective, observational study in Australia comparing SFED to swallowed budesonide
Molina-Infante et al (2014)73	Four-food elimination	52	54%*	SFED successful in 31% of FFED non-responders Milk was the most common trigger (50%)

SPT = Skin prick testing; APT = Atopy Patch Testing

^‡<10 eosinophils/hpf;

^*< 15 eosinophils/hpf