Table 1.

Non-Mendelian genetic contribution to intracerebral hemorrhage.

Ref.	Study type	Stroke subtype	Chr.	Gene landmark	Strongest association	Risk allele	Risk allele frequency	Odds ratio	p value
14	Candidate gene	Lobar ICH	19	APOE	rs429358 / rs7412	e2	0.12	1.82	6.6 × 10-10
14	Candidate gene	Lobar ICH	19	APOE	rs429358 / rs7412	e4	0.12	2.20	2.4 × 10-11
15	GWAS	Nonlobar ICH	1	PMF1 / SLC25A44	rs2984613	C	0.32	1.33	2.2 × 10-10
16	GWAS	Nonlobar ICH	13	COL4A2	rs9588151	T	0.34	1.23	5.54 × 10-9
17	Candidate gene Sequencing	Lobar + Nonlobar ICH	13	COL4A1	c.C1055T	T	<0.01	-	-
					c.C1612G	G
18	Candidate gene Sequencing	Lobar + Nonlobar ICH	13	COL4A2	c.C3448A	A	<0.01	-	-
					c.G5068A	A
					c.A3368G	G

Ref. = Reference; Chr. = chromosome; ICH = intracerebral hemorrhage. Odds ratio and p-value are not reported for the last two rows because these sequencing studies found rare variants to be present in a few cases and none of the controls, precluding formal association testing.