Table 1.

Top network nodes ranked by LAC, eigenvector centrality and betweenness scores. (The genes from the original seed set are highlighted in red. The common seed genes identified by all three methods are in red text and underlined

Gene/Chemical	LAC	Gene/Chemical	Eigenvector	Gene/Chemical	Betweenness
CDKN1A	9	TP53	0.293992	APP	40725.25
TP53	8.441559	APP	0.242665	HNF4A	24356.68
APOE	8	ESR1	0.235588	ELAVL1	23250.77
MYC	7.107143	MYC	0.225831	Gpcr	21763.95
PPARG	7.032258	UBC	0.194388	TP53	20339.18
YWHAQ	6.571429	CDKN1A	0.188231	ESR1	15732.38
SMARCA4	6.5625	HNF4A	0.179053	UBC	13405.76
RNA polymerase II	6.5	AR	0.167393	MYC	10966.7
RB1	6.307693	ELAVL1	0.163778	CREB1	9632.628
AR	6.243902	EGFR	0.159149	NXF1	7906.177
HSPA8	6.24	PPARG	0.15383	EGFR	7797.91
APOA1	6.214286	SMARCA4	0.150114	VHL	7234.26
Hsp70	6	YWHAZ	0.149565	YWHAZ	7099.747
APOC2	6	YWHAQ	0.144655	AR	7044.75
ESR1	5.768116	RB1	0.134934	DLG4	6159.478
TERT	5.666667	HSPA8	0.134347	PPARG	5938.707
Histone h3	5.6	CREB1	0.132037	GRB2	5115.18
EGFR	5.55	APOA1	0.130066	VCP	5050.226
APOB	5.5	RNA polymerase II	0.121485	REL	4567.824
NFkB (complex)	5.375	APOE	0.118555	APOA1	4350.606
APOC1	5.333334	GRB2	0.116974	GPR12	3997.739
APOA5	5.333334	VHL	0.115261	collagen	3765.427
SCARB1	5.142857	Hsp70	0.114036	CDKN1A	3632.875
UBC	5.107143	VCP	0.110983	SMARCA4	3361.238
Histone h4	4.888889	Histone h3	0.110957	F2R	3271.263
estrogen receptor	4.769231	TERT	0.106133	YWHAQ	3228.63
HDL	4.666667	ZFP36	0.09736	CXCL12	3088.951
Akt	4.571429	PPARA	0.096878	ZFP36	2985.264
YWHAZ	4.444445	NFkB (complex)	0.090869	LATS2	2786.828
N-cor	4.4	REL	0.085653	RB1	2672.204