Table 1.
In Vivo Results
| Before Therapy | After Therapy | Variation (%)∗ | p Value | |
|---|---|---|---|---|
| Shear wave imaging | ||||
| Elastography (kPa) | 76.1 ± 23.7 | 35.6 ± 7.2 | −52 ± 7 | <0.001 |
| Echocardiography | ||||
| Doppler mitral valve (Figure 5) | ||||
| Maximal velocity, m/s | 2.41 ± 0.50 | 1.73 ± 0.21 | −28 ± 6 | 0.007 |
| Maximal pressure gradient, mm Hg | 24.0 ± 4.4 | 12.1 ± 1.4 | −49 ± 11 | 0.003 |
| Mean velocity, m/s | 1.95 ± 0.36 | 1.38 ± 0.24 | −29 ± 6 | 0.001 |
| Mean pressure gradient, mm Hg | 16.2 ± 3.2 | 8.2 ± 1.3 | −48 ± 7 | <0.001 |
| Mitral valve area, cm2 | ||||
| By pressure half time (Figure 5) | 1.09 ± 0.09 | 1.57 ± 0.08 | +143 ± 18 | <0.001 |
| By continuity equation | 1.10 ± 0.15 | 1.58 ± 0.15 | +142 ± 15 | <0.001 |
| By planimetry (Figure 5) | 1.13 ± 0.13 | 1.54 ± 0.14 | +137 ± 14 | <0.001 |
| Pulmonary artery pressure, mm Hg | ||||
| Maximal (tricuspid valve) | 64.7 ± 12.8 | 34.1 ± 10.2 | −47 ± 12 | <0.001 |
| Cardiac output,† l/min | 2.98 ± 0.10 | 2.96 ± 0.14 | −1.0 ± 0.2 | 0.83 |
| Pressure sensors (Millar), mm Hg | ||||
| Mean diastolic LAP | 36.8 ± 6.2 | 20.2 ± 5.1 | −44 ± 11 | 0.004 |
| Mean diastolic LVP | 17.4 ± 2.7 | 11.4 ± 1.9 | −35 ± 10 | 0.014 |
| Mean diastolic gradient LVP-LAP | 17.4 ± 2.4 | 8.8 ± 1.2 | −50 ± 13 | 0.002 |
| Cardiac flow captor (l/min) | ||||
| Swan-Ganz catheter | 2.87 ± 0.11 | 2.96 ± 0.14 | +3.0 ± 0.4 | 0.74 |
Values are mean ± SD.
HR = heart rate; LAP = left atrial pressure; LVOT = left ventricular outflow tract; LVP = left ventricular pressure; VTI = velocity time integral.
∗
Variation = ([result after – result before]/result before) × 100.
†
Cardiac output = HR × LVOT area × LVOT VTI.