Table 1.
List of interventional clinical trials with pancreatic cancer patients using natural products.
| Agent and Trial No. | Trial Status | Phase | No. of Patients | Disease Stage | Location/Site | Sources of nature products |
|---|---|---|---|---|---|---|
| Curcumin | ||||||
| NCT00094445 (Ref 41) | Completed | II | 50 | Advanced, metastatic, or recurrent | M.D. Anderson Cancer Center | Sabinsa Corporation |
| NCT00192842 | Completed | II | 17 | Locally advanced or metastatic | Rambam Health Care Campus | - |
| NCT00486460 | Unknown | III | - | - | Tel-Aviv Sourasky Medical Center | - |
| Vitamin C (ascorbate) | ||||||
| NCT01049880 (Ref 79) | Completed | I | 15 | Metastatic | University of Iowa, Holden Comprehensive Cancer Center | Ascorbic Acid Injection USP, Bioniche Pharma |
| NCT02896907 | Recruiting | I | 8 | Locally advanced unresectable or Recurrent | Sidney Kimmel Cancer Center, Thomas Jefferson University | - |
| NCT00954525 (Ref 80) | Completed | I | 14 | Metastatic | Thomas Jefferson University | Ascorbic Acid Injection USP, Bioniche Pharma |
| NCT01905150 | Recruiting | II | 30 | Metastatic, locally advanced unresectable, or locally recurrent | Bruckner Oncology, Bronx, New York | - |
| Vitamin D | ||||||
| NCT02754726 | Recruiting | II | 10 | Metastatic | HonorHealth Research Institute | Paricalcitol |
| Vitamin E δ-tocotrienol | ||||||
| NCT00985777 (Ref 84) | Completed | I | 26 | Resectable | H. Lee Moffitt Cancer Center and Research Institute | Pure vitamin E δ-Tocotrienol |
| Fish oil | ||||||
| NCT01019382 (Ref 85) | Completed | II | 50 | Unresectable | University Hospitals, Leicester | Lipidem, B. Braun Melsungen AG |
| NCT01256034 (Ref 86) | Completed | IV | 50 | Resectable | Chiba University, Japan | Oral Impact®, Nestlé |
| NCT01789073 (Ref 87) | Completed | Not available | 35 | Resectable | University of Copenhagen | Oral Impact®, Nestlé |
| Fish oil + vitamin E | ||||||
| NCT02681601 | Not yet Recruiting | Not available | 60 | Unresectable | Jonsson Comprehensive Cancer Center, The University of California Los Angeles | OmegaRich, NutraWell nutrition powder, New Health Enterprises |
| Genistein | ||||||
| NCT00882765 | Withdrawn prior to enrollment. | II | - | - | Jonsson Comprehensive Cancer Center, The University of California Los Angeles | - |
| Broccoli Sprout | ||||||
| NCT01879878 | Unknown | Not available | 40 | Advanced, unrese ctable | Heidelberg University, Germany | Broccoli sprout grain |
| L-CARnitine | ||||||
| NCT01330823 | Suspended | III | 72 | Advanced | University Medicine Greifswald | - |
| Dietary supplements without defined ingredients | ||||||
| NCT01947166 | Completed | Not available | 38 | Resectable | Duke University | Nestle Impact Advanced Recovery nutritional supplement |
| NCT02745197 | Not yet Recruiting | II | 88 | Resectable | University of Alberta | - |
| NCT02626195 | Recruiting | II | 50 | Resectable | National Cancer Center, Korea | - |
| NCT02940067 | Recruiting | Not available | 40 | Resectable | University of Surrey | MEDiterranean diet |
| NCT00003851 | Terminated | 90 | Unresectable primary or metastatic | Columbia University | Gonzalez Regimen | |
| NCT00049608 | Terminated | I | 51 | Metastatic, recurrent, or unresectable locally advanced | National Cancer Institute (NCI) | Mistletoe extract |
| NCT01838109 | Completed | Not available | 174 | Resectable | Seoul National University Hospital | - |
| NCT01642875 | Recruiting | IV | 96 | Resectable Primary periampullary tumor | Medical University of Warsaw | - |
| NCT02670265 | Completed | Not available | 100 | Biliopancreatic Mass Lesions | University Medicine Greifswald | Olimel peri 2.5 %®, Baxter Germany GmbH Medication Delivery |
| NCT01419483 | Suspended | I | 5 | IIA, IIB, or III | University of Iowa | Ketogenic diet |
| NCT00919659 | Completed | II | 32 | With progressive cancer cachexia | CONKO-Studiengruppe | - |
| NCT02336087 | Recruiting | I | 21 | Unresectable | City of Hope Medical Center; NCI | Standardized Dietary Supplement |