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Neurons were treated with 5 mM lactate, the MCT inhibitor 4-CN (100 μM final), or a combination of lactate and 4-CN for 48 hours prior to lethal OGD. 48 hours following lethal OGD, cell death was measured with LDH-release assay and normalized to NMDA-induced LDH release. MCT: monocarboxylate transporter. 4-CN: Alpha-cyano-4-hydroxycinnamate. n = 4-5, *p<0.05.
