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. Author manuscript; available in PMC: 2018 Jul 17.
Published in final edited form as: Nature. 2018 Jan 17;553(7688):295–300. doi: 10.1038/nature25440

Extended Data Figure 6. Comparison between Pol III in the OC and elongating states.

Extended Data Figure 6

Superposition of elongating Pol III (ePol, PDB 5fj8) and Pol III in the OC. In the OC, the heterotrimer moves towards upstream DNA and the C34 WH1 and WH2 domains become ordered. The stalk moves towards the heterotrimer, and the clamp moves to slightly close the cleft. The C37 initiation/termination loop becomes partially ordered to interact with the Bdp1 tether and C34 WH1 and WH2.