Skip to main content
. Author manuscript; available in PMC: 2018 Jul 17.
Published in final edited form as: Nature. 2018 Jan 17;553(7688):295–300. doi: 10.1038/nature25440

Extended Data Figure 9. Comparison between Bdp1 in the Pol III-PIC and TFIIA and TFIIF in the Pol II-PIC.

Extended Data Figure 9

The Bdp1 SANT domain is located at a similar position as TFIIA. Parts of Bdp1 resemble TFIIF subunit Tfg1, although no sequence similarity is detectable. Both interact with the Pol protrusion by adding a β-strand to the Pol protrusion (although at different ends of the protrusion β-sheet) and fold into a short helix along the face of the protrusion. The path of the C37 initiation/termination loop is also similar to Tfg1. The second subunit of TFIIF, Tfg2, also adds a β-strand to the Pol II protrusion. Brf1 and TBP were omitted for clarity.