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. Author manuscript; available in PMC: 2018 Jul 17.
Published in final edited form as: Nature. 2018 Jan 17;553(7688):295–300. doi: 10.1038/nature25440

Figure 2. TFIIIB interactions with C34 and C37 in the PIC.

Figure 2

Top panel: Location of TFIIIB on Pol III (left) and schematic view of interactions that stabilize C34 in the position observed in the OC/ITC structures (right). Bottom left: Close up view of the Bdp1 tether. Interactions between Bdp1 tether, Pol III protrusion, C37 initiation/termination loop and C34 WH1 and WH2 are highlighted. Regions that contact the Bdp1 tether are depicted in solid color, other elements are transparent. Bottom right: Close up view of C34 WH2. C34 WH2 is stabilized by both arms of TFIIIB, Pol III protrusion and C37.