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. 2018 Jan 9;14(1):e1007133. doi: 10.1371/journal.pgen.1007133

Fig 6. Folate transporter gene copy number is correlated with greater sensitivity to methotrexate.

Fig 6

Effect of Methotrexate on parasite growth (%Dead) was plotted as a function of the total gene copy number of folate (LdBPK_100380; LdBPK_100390; LdBPK_100400 and LdBPK_100410) and biopterin transporters (LdBPK_355160) showing variation on chromosomes 10 and 35, respectively (FT+BT). CN was predicted by cn.mops. %Dead—percentage parasites killed following incubation with 0.5mg/ml methotrexate as described in Material and Methods. Average of n = 3 independent experiments ± s.e. Isolates from southern Ethiopia (SE) have codes beginning with AM. Isolates from northern Ethiopia (NE) have codes beginning with GR.