Figure 2.

Simulations of the concentration–time course of tranexamic acid (TXA). Panels A and C show predicted concentrations of TXA after a 1 g bolus. Panels B and D show predicted concentrations of TXA after a 1 g bolus followed by an additional infusion of 1 g over 8 h. Panels A and B illustrate the effect of total body weight on maximum plasma TXA concentration in a patient with a creatinine clearance (CrCL) of 85 ml min⁻¹ and weighing 50 kg (red line), 70 kg (green line) or 100 kg (blue line). Panels C and D illustrate the effect of CrCL on TXA exposure over time in a patient weighing 70 kg with a CrCL of 30 ml min⁻¹ (red line), 85 ml min⁻¹ (green line) or 150 ml min⁻¹ (blue line). y‐axes are on a log‐scale