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. 2017 Dec 7;8(70):114481–114494. doi: 10.18632/oncotarget.23010

Figure 5. Biphasic regulation of cellular metabolism driven by GS and HIF-1α.

Figure 5

(A–F) Glucose (A, C, E) or glutamine (B, D, F) dependency were determined in CD90− and CD90+ PEO1 cells (A, B), in CD90+ cells for GS knockdown (C, D) or for HIF-1α knockdown and overexpression over KD (E, F). Glucose/glutamine dependencies were determined using the Seahorse Mito Fuel Flex test. The data show the mean of at least n = 3 independent experiments. Error bars indicate s.e.m. *P < 0.05; **P < 0.01; ***P < 0.001 (Student’s t-test).