Figure 2. CXCR2⁺ MDSCs are relevant to breast cancer lymph node metastasis.

(A) Representative image of mice with or without axillary lymph node metastasis in 4T1 tumor-bearing mice using in vivo bioluminescence imaging. (B) Metastatic axillary lymph nodes were confirmed by bioluminescence imaging. (C) Percentage of CXCR2⁺ MDSCs in immune cells of peripheral blood from 4T1 tumor-bearing mice with or without axillary lymph node metastasis. (D) Number of CXCR2⁺ MDSCs in 1g spleen of 4T1 tumor-bearing mice with or without axillary lymph node metastasis. (E) Percentage of CXCR2⁺ MDSCs in immune cells of axillary lymph nodes from 4T1 tumor-bearing mice with or without axillary lymph node metastasis. (F) Number of CXCR2⁺ MDSCs in 1g primary tumor of 4T1 tumor-bearing mice with or without axillary lymph node metastasis. ^*P < 0.05,^***P < 0.001. Data was presented by mean ± sem.