Figure 5. Differences of aDNAm’s by tissue types and breast cancer types.
(A) Mean methylation level for all 437,653 CpGs analyzed and mean 1,214 aDNAm’s by different tissue types. Comparison was performed between breast normal tissues from healthy women and TCGA adjacent normal and tumor. Separately, comparison for only paired adjacent normal and tumor tissues from TCGA is also shown. Comparison of mean 1,214 aDNAm’s by breast cancer types (B) or hormone receptor status (C–E) among TCGA tumor tissues. The differences between tissue types or cancer types were tested using Mann-Whitney rank tests.
