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. 2017 Nov 29;8(70):114648–114662. doi: 10.18632/oncotarget.22754

Figure 6. aDNAm’s in TCGA datasets.

Figure 6

(A) A pie chart by exploding sections for replicated (Y) or non-replicated (N) aDNAm’s in TCGA adjacent normal and/or tumor tissues. A proportion of genomic features (functional promoters, CpGIslands, enhancers) and top molecular and cellular functions by IPA for each section are shown. (B) Differences for methylation levels of 732 aDNAm’s replicated in TCGA tumor tissues by hormone receptor status (positive and negative). The differences were tested using Mann-Whitney rank tests and Benjamini and Hochberg False Discovery Rate (FDR) q < 0.05 was considered significant. In pie charts, higher and lower methylation of differentially methylated aDNAm’s in positive compared to negative hormone receptor status are shown as red and blue section, respectively.