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. 2017 Dec 1;8(70):114698–114709. doi: 10.18632/oncotarget.22815

Figure 5.

Figure 5

(A) Graph: BLI analysis of Nod.Cg-PrkdcscidII2rgtm-Gammanull mice. For this analysis, the highest value of bioluminescence acquired for each animal was chosen. (B) Histological tumor sample (H and E). Histologic sample obtained from RPMI8226-LUC-PURO tumor tissue of untreated mouse (100 ×). (C) Immunohistochemical analysis of the histologic tumor sample. RPMI8226-LUC-PURO tumor tissue of untreated mouse (lambda positive) (400 ×). (D) Histological tumor sample (H and E). RPMI8226-LUC-PURO tumor tissue from mouse treated with bortezomib plus VER155008 showing tumor coagulative necrosis area and apoptotic cells (400×). (E) Histological tumor sample (H&E). The same image above with magnification 100 ×, showing tumor coagulative necrosis area (arrow) and apoptotic cells.