Figure 3.
(A) Imaging flow cytometry plots of CD9+/GFAP+/SVN+ exosomes in 3 patients who had late tumor progression (88.0-173.3 weeks) after the first of 4 doses of survivin vaccine. CD9+/GFAP+/SVN+ exosomes at baseline (pre-vaccine, left column) are shown; CD9+/GFAP+/SVN+ exosomes 8-10.3 weeks after receiving the first of four vaccine doses (middle column); and CD9+/GFAP+/SVN+ exosomes 12-22 months after receiving first of four doses of survivin vaccine (right column). Bottom row (B) demonstrates CD9+/GFAP+/SVN+ exosomes in 3 non-cancer healthy control individuals (no tumor, no vaccine).