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. 2017 Dec 1;8(70):114736–114745. doi: 10.18632/oncotarget.22827

Figure 3. HSD17B4 overexpression is associated with p53 signaling alteration.

Figure 3

(A) reproduction of TCGA ACC dataset showing heatmap of p53 signaling related genes in cases with and without HSD17B4 overexpression; (B) MDM4 expression is significantly lower in cases with HSD17B4 overexpression; (C) ATR expression is significantly higher in cases with HSD17B4 overexpression; enriched genes were confirmed for protein level using western blotting in (D) H295R cells with and without HSD17B4-KD, and in (E) SW13 cells with and without HSD17B4 replenish (*P < 0.05).