| Evidence of contraindications to MR examination (e.g. pacemaker, cochlear implant, etc.). |
| Incomplete MR acquisition or histopathological analysis. |
| Contraindication to the use of neoadjuvant therapy or surgical treatment. |
| Suspension of neoadjuvant combination chemotherapy-radiation treatment prior to surgery, presence of synchronous tumors, mucinous histotype, neurological or psychiatric disorders or previous pelvic radiotherapy. |
| Hypersensitivity to the study drug or to one of the excipients. |
| Legal incapacity. |
| Concurrent treatment with experimental drugs or participation in another clinical trial with any investigational drug within 30 days before study screening. |
| Alcohol or drug abuse. |
