Figure 8. Protein network depicting interactions among Jak-Stat signaling pathway proteins (extracted from KEGG) and proteins found with altered phosphorylation profiles.

Blue lines indicate binding, green lines indicate activation and red lines indicate inhibition, whereas purple lines indicate catalysis, pink lines indicate posttranslational modification, yellow lines indicate transcriptional regulation and black lines indicate a generic reaction. Arrows indicate a positive action, bars indicate a negative action and ball-ends indicate a directional interaction of unknown nature. Proteins are represented by gene names. The network was generated by STRING 10.0 [19].