Table 2. Testing for mutually exclusive mutation patterns found in melanoma tumors (n = 412) by the Comet Exact Test with multiple testing correction by the Bonferroni method.

Gene 1	Gene 2	NeitherMutated	Gene 2Mutated	Gene 1Mutated	BothMutated	p-value
BRAF	NRAS	98	110	196	8	2.49E-30
BRAF	NF1	160	48	190	14	4.34E-05
NRAS	PTEN	259	35	116	2	0.004565
NF1	MAP2K1	328	22	62	0	0.349177
BRAF	IDH1	194	14	198	6	1
BRAF	RB1	198	10	199	5	1
NF1	PTEN	316	34	59	3	1
PTEN	RB1	360	15	37	0	1
NRAS	NF1	246	48	104	14	1
NRAS	MAP2K1	276	18	114	4	1
PTEN	MAP2K1	354	21	36	1	1
BRAF	TP53	175	33	173	31	1
MAP2K1	IDH1	371	19	21	1	1
NF1	IDH1	333	17	59	3	1
PTEN	IDH1	357	18	35	2	1
MAP2K1	RB1	376	14	21	1	1
TP53	RB1	336	12	61	3	1
NF1	RB1	338	12	59	3	1
TP53	IDH1	332	16	60	4	1
TP53	MAP2K1	331	17	59	5	1
NRAS	RB1	285	9	112	6	1
TP53	PTEN	319	29	56	8	1
IDH1	RB1	379	13	18	2	1
NRAS	IDH1	283	11	109	9	1
TP53	NRAS	254	94	40	24	1
BRAF	MAP2K1	201	7	189	15	1
TP53	NF1	301	47	49	15	1
BRAF	PTEN	201	7	174	30	1