Table 3. Testing for mutually exclusive mutation patterns found in cell lines (n = 53) by the Comet Exact Test with multiple testing correction by the Bonferroni method.

Gene 1	Gene 2	NeitherMutated	Gene 2Mutated	Gene 1Mutated	Both Mutated	p-value
BRAF	NRAS	12	5	34	2	0.438538739
BRAF	MAP2K1	17	34	2	0	1
BRAF	IDH1	17	35	1	0	1
BRAF	RB1	17	35	1	0	1
BRAF	NF1	14	3	33	3	1
TP53	NF1	30	5	17	1	1
TP53	PTEN	30	5	17	1	1
TP53	MAP2K1	33	2	18	0	1
BRAF	TP53	10	7	25	11	1
NF1	PTEN	41	6	6	0	1
TP53	IDH1	34	1	18	0	1
TP53	RB1	34	1	18	0	1
NF1	MAP2K1	45	2	6	0	1
NRAS	IDH1	45	1	7	0	1
NRAS	RB1	45	1	7	0	1
NF1	IDH1	46	1	6	0	1
NF1	RB1	46	1	6	0	1
PTEN	IDH1	46	1	6	0	1
PTEN	RB1	47	5	1	0	1
MAP2K1	IDH1	50	1	2	0	1
MAP2K1	RB1	51	1	1	0	1
IDH1	RB1	51	1	1	0	1
NRAS	NF1	41	5	6	1	1
NRAS	PTEN	41	5	6	1	1
TP53	NRAS	31	4	15	3	1
BRAF	PTEN	16	1	31	5	1
NRAS	MAP2K1	45	1	6	1	1
PTEN	MAP2K1	46	1	5	1	1