Figure 1. Ino80 haploinsufficiency inhibits intestinal tumorigenesis in Apc^min/+ mice.

(A) Ino80^+/+Apc^min/+ and Ino80^+/−Apc^min/+mice were killed when they were 100 days old. The intestines were isolated to count the number of polyps. Representative microscopic images (top) and hematoxylin and eosin-stained samples (bottom) of small intestinal polyps are shown. Magnification, x40. (B) The number of small intestinal polyps in the indicated mouse lines (n = 12 for each group) was plotted as a graph in which each dot represents the total polyp number in a single mouse. The horizontal bar indicates the mean value. The p values were determined using the Wilcoxon rank-sum test. (C) Kaplan–Meier survival curve comparing survival in the indicated mice (median survival: Ino80^+/+Apc^min/+=153.5 days vs Ino80^+/−Apc^min/+ = 190.5 days; n = 10 per group). The p value was determined using the log-rank test. (D) The size distribution of small intestinal polyps obtained from the indicated mice. The data were obtained from the results shown in (A). ^**p < 0.01; ^***p < 0.001. N.S., not significant. Error bars, mean ± SD.