Figure 6. Ino80 haploinsufficiency activates Chk1 in intestinal tumors in Apc^min/+ mice.

Representative results are shown for p-Chk1-S317 and p-Chk1-S345 immunostaining in size-matched small intestinal tumors obtained from the indicated mice when they were 100 days old. Original magnification, × 200. Five tumoral regions per mouse were designated regions of interest (ROI), and their mean immunostaining intensities were quantified using TissueFAXS. The quantitation data are illustrated as a graph and shown next to the corresponding immunostaining images. Error bars, mean ± SD of results from three different mice.