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. 2017 Nov 25;8(70):115128–115139. doi: 10.18632/oncotarget.22924

Figure 2. Validation of A/J mouse lung cancer model induced by smoke exposure.

Figure 2

(A) All of the A/J mice form lung tumors 9 months after smoke exposure. H&E staining shows: 2 cases of adenoma, 8 cases of adenocarcinoma; immunohistochemical study for 8 cases of adenocarcinoma show: TTF - 1 was strong positive, P63 and CK56 were negative, confirming the finding of adenocarcinoma. (B) Compared with control lung tissue, the expression of antiapoptotic proteins XIAP and Survivin in mice with lung cancer is significantly higher (P < 0.01). TUNEL staining demosntrates the apoptosis rate of tumor tissue is significantly lower compared with lung tissue of control mice (P < 0.01).