Table 1. The correlation of smoking and Notch1 coding sequcence mutation.
| Location | Sequence variation | SNP ID | Amino acid variation | Mutation sequence | Frequency (%) in smoker and never smoker |
|---|---|---|---|---|---|
| exon27 | c.5094C>T | rs10521 | p.Asp1698= | GTGCCACCGA[T/T]GTGGCCGCAT | Smoker:15.8%* Non-smoker:6.7% |
| exon14 | c.2265T>C | rs2229971 | p.Asn755= | TCAACAACAA[C/C]GAGTGTGAAT | Smoker:57.9%* Non-smoker:60% |
| exon34 | c.6555C>T | rs2229974 | p.Asp2185= | AGTCCCAGGA[T/T]GGCAAGGGCT | Smoker:42.1%* Non-smoker:46.7% |
| exon34 | c.6648G>A | rs3812596 | p.Pro2216= | TGGCCTCGCC[A/G]CCACTGCTGC | Smoker:10.5%* Non-smoker:6.7% |
| exon3 | c.312T>C | rs4489420 | p.Asn104= | CCCTGGACAA[C/C]GCCTGCCTCA | Smoker:15.8%* Non-smoker:6.7% |
*P<0.05 Smoker vs Never-smoker (Fisher’s Exact Test).