Table 2. The correlation of smoking and Notch2 coding sequcence mutation.
| Location | Sequence variation | SNP ID | Amino acid variation | Mutation sequence | Frequency (%) in smoker and never smoker |
|---|---|---|---|---|---|
| exon1 | c.57C>G | rs11810554 | p.Cys19= | GGCTGTGCTG[C/G] GCGGCCCCCG |
Smoker:10.5%* Non-smoker:13.3% |
| exon4 | c.710G>A | rs146498360 | p.Arg237Gln | GGCACCTGTC[A/G] GCAGACTGGT |
Smoker:21.0%* Non-smoker:0 |
| exon1 | c.61G>A | rs2603926 | p.Ala21Thr | GTGCTGCGCG[A/A] CCCCCGCGCA |
Smoker:31.6%* Non-smoker:6.7% |
| exon28 | c.5065A>T | rs60854092 | p.Ile1689Phe | TGTTGTCATC[A/T] TTCTGTTTAT |
Smoker:10.5%* Non-smoker:0 |
| exon34 | c.7042T>C | rs61734328 | p.Leu2348= | AATGGCCCGT[C/T] TGCCCAGTGT |
Smoker:10.5%* Non-smoker:0 |
| exon20 | c.3234C>T | rs7543643 | p.Cys1078= | AAGGTACTTG[C/T] GTTCAGAAAA |
Smoker:10.5%* Non-smoker:13.3% |
| exon4 | c.572A>T | Novel | p.His191Leu | ATTCCAGGAC[A/T] CTGCCAGCAT |
Smoker:10.5%* Non-smoker:0 |
| exon17 | c.2622T>C | Novel | p.Ile874= | CCATTGACAT[C/C] GACGAGTGTA |
Smoker:10.5%* Non-smoker:0 |
| exon18 | c.2882G>A | Novel | p.Gly961Glu | TGTAAGAATG[A/A] AGGGACCTGC |
Smoker:15.8%* Non-smoker:0 |
*P<0.05 Smoker vs Never-smoker (Fisher’s Exact Test).