Table 2. Hematological parameters of nude mice bearing MKN-45 cell xenograft tumors.
Hematological parameters | Normal | Vehicle | 5-FU 10 mg/kg | CT | Standard | |
---|---|---|---|---|---|---|
1 mg/kg | 10 mg/kg | |||||
White blood cells (109/L) | 9.98±1.54 | 9.48±3.14 | 10.75±1.78 | 10.29±1.11 | 10.82±1.39 | 4.0-12.0 |
Lymphocytes percentage (%) | 65.01±17.02 | 50±17.74 | 69±10.6 | 73.65±7.2 | 70.85±13.55 | 54.0-85.0 |
Middle cells percentage (%) | 1.59±0.77 | 1.43±0.82 | 1.54±0.53 | 1.19±0.47 | 1.65±0.07 | 0.0-20.0 |
Granulocyte percentage (%) | 33.4±6.74 | 27.7±8.47 | 19.3±5.78 | 16.17±7.25 | 22.5±3.48 | 12.0-44.0 |
Lymphocytes (109/L) | 6.72±1.58 | 6.46±2.1 | 7.75±0.78 | 5.09±1.05 | 5.46±1.59 | 3.0-8.5 |
Middle cells (109/L) | 0.15±0.12 | 0.11±0.06 | 0.09±0.04 | 0.02±0.05 | 0.07±0.01 | 0.0-2.0 |
Granulocyte (109/L) | 2.12±1.58 | 3.33±1.65 | 2.86±1.58 | 4.19±1.31 | 2.27±2.23 | 0.7-5.0 |
Red blood cells (1012/L) | 10.46±0.13 | 10.6±0.08 | 10.38±0.20 | 9.89±1.21 | 9.06±1.04 | 7.0-12.5 |
Hemoglobin (g/L) | 152.57±14.16 | 161.25±3.77 | 159.45±5.26 | 170.15±2.99 | 149±15.25 | 100-190 |
Mean corpuscular volume (fL) | 57.57±0.53 | 56.25±0.5 | 56.55±0.52 | 56.38±0.65 | 55.5±0.71 | 51.0-65.0 |
Hematokrit (L/L) | 0.5±0.01 | 0.49±0.03 | 0.48±0.01 | 0.51±0.01 | 0.46±0.05 | 0.35-0.55 |
Mean corpuscular hemoglobin (Pg) | 18.1±5.57 | 19.8±1.27 | 20.01±0.36 | 18.93±1.74 | 18±1.41 | 12.0-30.0 |
Mean corpuscular hemoglobin concentration (g/L) | 314.86±6.89 | 285.75±3.86 | 295±6.93 | 270.62±13.18 | 301.5±10.51 | 230-330 |
Red blood cell distribution width_SD (fL) | 41.4±0.27 | 40.63±0.39 | 40.85±0.41 | 40.3±1.19 | 39.15±2.05 | 15.0-55.0 |
Red blood cell distribution width_CV (%) | 21.83±0.08 | 21.93±0.13 | 21.9±0.09 | 21.68±0.43 | 21.25±0.78 | 12.0-30.0 |
Blood platelet (109/L) | 186.29±34.43 | 144.25±29.96 | 218.91±21.02 | 214.38±47.93 | 200.5±54.45 | 100-300 |
Mean platelet volume (fL) | 6.67±0.7 | 6.95±0.49 | 7.25±0.33 | 7.1±0.81 | 7.2±0.57 | 6.1-12.0 |
Thrombocytocrit (L/L) | 0.12±0.04 | 0.1±0.03 | 0.16±0.02 | 0.15±0.04 | 0.14±0.03 | 0.10-0.60 |
Platelet distribution width (%) | 15.89±0.37 | 15.15±0.21 | 15.46±0.24 | 15.67±0.35 | 15.14±0.37 | 1.0-30.0 |
Note: Blood samples were taken after CT or 5-FU treatment for 20 days.