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. 2017 Dec 14;8(70):115469–115479. doi: 10.18632/oncotarget.23300

Table 5. Toxicity from IC and CCRT between the two arms.

Adverse event (toxicity grade) IC CCRT
TPF arm TP arm p TPF arm TP arm p
1-2 3-4 1-2 3-4 1-2 3-4 1-2 3-4
Hematologic
 Leukocytopenia 99 143 172 50 <0.001 163 22 154 46 0.516
 Neutropenia 60 162 145 55 <0.001 142 43 138 33 0502
 Anemia 73 4 87 7 0.157 60 0 79 0 0.691
 Thrombocytopenia 48 4 49 3 0.128 51 13 36 7 0.975
 Liver function 154 4 105 2 0.520 47 0 43 0 0.055
 Renal function 7 0 7 0 0.254 13 0 11 0 0.277
Non-hematologic
 Mucositis 30 0 25 0 0.874 232 13 232 13 1.0
 Dermatitis 13 0 8 0 0.559 239 6 241 4 0.518
 Diarrhea 77 4 19 0 0.033 22 4 17 2 0.770
 Nausea/vomiting 47 4 35 4 0.937 34 1 33 3 0.099

Abbreviations: IC, induction chemotherapy; CCRT, concurrent chemoradiotherapy.