Table 5. Toxicity from IC and CCRT between the two arms.
Adverse event (toxicity grade) | IC | CCRT | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
TPF arm | TP arm | p | TPF arm | TP arm | p | |||||
1-2 | 3-4 | 1-2 | 3-4 | 1-2 | 3-4 | 1-2 | 3-4 | |||
Hematologic | ||||||||||
Leukocytopenia | 99 | 143 | 172 | 50 | <0.001 | 163 | 22 | 154 | 46 | 0.516 |
Neutropenia | 60 | 162 | 145 | 55 | <0.001 | 142 | 43 | 138 | 33 | 0502 |
Anemia | 73 | 4 | 87 | 7 | 0.157 | 60 | 0 | 79 | 0 | 0.691 |
Thrombocytopenia | 48 | 4 | 49 | 3 | 0.128 | 51 | 13 | 36 | 7 | 0.975 |
Liver function | 154 | 4 | 105 | 2 | 0.520 | 47 | 0 | 43 | 0 | 0.055 |
Renal function | 7 | 0 | 7 | 0 | 0.254 | 13 | 0 | 11 | 0 | 0.277 |
Non-hematologic | ||||||||||
Mucositis | 30 | 0 | 25 | 0 | 0.874 | 232 | 13 | 232 | 13 | 1.0 |
Dermatitis | 13 | 0 | 8 | 0 | 0.559 | 239 | 6 | 241 | 4 | 0.518 |
Diarrhea | 77 | 4 | 19 | 0 | 0.033 | 22 | 4 | 17 | 2 | 0.770 |
Nausea/vomiting | 47 | 4 | 35 | 4 | 0.937 | 34 | 1 | 33 | 3 | 0.099 |
Abbreviations: IC, induction chemotherapy; CCRT, concurrent chemoradiotherapy.