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. 2017 Dec 14;8(70):115596–115608. doi: 10.18632/oncotarget.23313

Figure 7. Model for Sur8 stability regulation by FGF2 signaling.

Figure 7

In the resting state (left panel), Sur8 is maintained at a low level by PKCα- and PKCδ-mediated phosphorylation at Thr-71 and Ser-297, respectively, and is subsequently degraded. This results in a basal level of cell proliferation. Upon FGF2 stimulation (right panel), Sur8 is maintained at a high level by stabilization through degradation of PKCα/δ. The stabilized Sur8 promotes transformation and migration of cells via activation of the Ras/ERK pathway.