Table 1. MiRNAs involved in CDDP-resistance of NSCLC cells mainly assigned to cell proliferation and cell cycle pathways.
| miRNA | Targets | Cells / Tissue | Expression | Function | Reference |
|---|---|---|---|---|---|
| miR-1 | SDF-1 | Cancer-associated fibroblasts (CAFs) | down | Negatively regulates SDF-1 and influence CDDP-resistance in CAFs | [106] |
| mR-21 | PTEN | Serum, NSCLC cells | up | Correlates with TNM stage, increases growth | [9] |
| miR-25 | CDC42 | NSCLC tissue, A549/PAR | up | Increases proliferation, decreases CDDP-sensitivity | [24] |
| miR-29b | CDK6, DNMT3B, MCL1 | A549 cells | down | Reduces expression of CDK6, inhibits cell growth | [107] |
| miR-34a | SIRT1 | NSCLC tissue, A549/PAR | down | Sensitizes NSCLC cells to CDDP | [108] |
| miR-92b | PTEN | NSCLC tissue, A549/PAR | up | Oncogene, inhibits apoptosis, induces cell growth and resistance to CDDP | (46) |
| miR-98 | PAK1 | NSCLC tissue, A549/PAR | down | Inversely regulates PAK1, inhibits proliferation | (87) |
| miR-98-5p | P53 | NSCLC cells | up | Inhibition of miR-98-5p increases p53 expression and CDDP efficacy | [109] |
| miR-107 | CDK8 | A549/PAR | down | Neg. regulates CDK8, inhibits cell growth, has a key role in CDDP-resistance | [21] |
| miR-135b | FZD1 | A549/CDDP | down | Suppresses CDDP-resistance in NSCLC by targeting FZD1 | [110] |
| miR-137 | NUCKS1 | NSCLC tissue, A549/CDDP | down | Down-regulation promotes cell growth, migration and G1/S transition | [111] |
| miR-138 | CCND3 | NSCLC cells | down | Negatively regulates CDDP-resistance, influences cell migration | [40] |
| miR-145 | CDK6 | NSCLC cells/CDDP | up | Indirectly influences DCK6 expression and CDDP-resistance | [22] |
| miR-146a | CCNJ | A549/CDDP | down | Increases the sensitivity to CDDP, targets drug-resistance-associated proteins | [112, 113] |
| miR-181b | TGFßR1 | A549/CDDP | down | Influence CDDP-resistance by targeting TGFßR1/Smad pathway | [114] |
| miR-182 | PDCD4 | A549/PAR | up | Inversely regulates PDCD4 expression, influences CDDP-resistance | [84] |
| miR-196a | n. d. | A549/CDDP | up | Regulates MDR1, MRP1, ERCC1, surviving, Bcl2 and RhoE | [115] |
| miR-216a | eIF4B, ZEB1 | NSCLC tissue | down | Tumor suppressor miRNA, influences CDDP-induced apoptosis | [12] |
| miR-224 | P21(WAF1/CIP1) | A549/CDDP | up | Promotes CDDP-resistance via regulating G1/S transition and apoptosis | [116] |
| miR-432 | E2F3, AXL | NSCLC tissue, NSCLC cells | down | Negatively correlates with E2F3 and AXL and influence CDDP-resistance | [117] |
| miR-486-5p | PIM-1 | NSCLC cells, NSCLC tissue | down | Negatively regulates Pim-1 and decreases sensitivity to CDDP | [118] |
| miR-630 | CDC7 | NSCLC cells | up | Has a bimodal role in regulation of DNA-damage and apoptosis | [23] |
n. d., not defined; Expression = expression in CDDP-resistant cells or NSCLC tissue in comparison to sensitive cells or non-malignant lung tissue.