Table 4. Hypoxia-deregulated miRNAs in NSCLCs.
| miRNA | Target genes | Correlationwith HIF-1α | Entity (regulation under HOX) | Main function of miRNA | Reference |
|---|---|---|---|---|---|
| miR-15a | n. d. | neg. | NSCLC (down) | n. d., miR-15a expression negatively correlates with HIF-1α | [132] |
| miR17-92 cl. | HIF-1α | neg. | Lung cancer (up) | Mediate HIF-1α inhibition of cell growth in normoxic conditions | [133] |
| miR-21 | HIF-1α | pos. | Adenocarcinoma and radioresistant NSCLC (up) | Influences cancer cell adaptation to tumor-specific environment, promotes glycolysis and modulates radioresistance by upregulation of HIF-1α | [134–136] |
| miR-23a | PHD1, PHD2, ZO-1 | pos. | Adenocarcinoma (up) | Enhances neovascularization and tumor growth | [137] |
| miR-101 | Cox2, Lin28B, let-7 miRNA | neg. | NSCLC (down) | Tumor suppressive function in NSCLC | [138] |
| miR-143 | IGF-IR, IRS1 | neg. | Cr (VI)-transformed lung epithelial cells (down) | Antiangiogenic effects | [139] |
| miR-155 | FOXO3A, TP53INP1 | pos. | NSCLC (up) | Shows radio-protective effect in NSCLC cell lines | [140] |
| miR-191 | NF1A | pos. | NSCLC (up) | Promotes cell proliferation and migration under HOX | [141] |
| miR-199a | HIF-1α | neg. | NSCLC (down) | Suppresses hypoxia-induced proliferation of NSCLC cell | [96] |
| miR-210 | NDUFA4, SDHD, PTPN1, TP53I11, HOXA1, HIF-1α | pos. | NSCLC, NSCLC - late stage (up) | Influences cell viability, activates caspase 3/7, promotes double-strand break repair, and increases radioresistance in NSCLC cells. | [92, 142, 143] |
| miR-301b | Bim | pos. | NSCLC specimens and cell lines (up) | Enhances cell proliferation, reduces apoptosis, increases resistance to chemotherapy | [144] |
| miR-494 | PTEN | pos. | NSCLC cells (up) | Enhances endothelial cell migration, promotes angiogenesis and tumor growth under HOX | [97] |
| miR-519c | HIF-1α | neg. | NSCLC cells (n. d.) | Suppresses tumor angiogenesis, growth, and metastasis | [145] |
| miR-622 | HIF-1α | neg. | NSCLC cells (down) | Inhibits cancer cell migration and invasion | [99] |
| miR-1908 | AKT1S1 | n. d. | NSCLC (down) | Suppresses cell proliferation | [146] |
HOX, hypoxia; neg., negative; pos., positive; cl., cluster; n. d., non-determined; NSCLC, non-small cell lung carcinoma; CTL, cytotoxic T lymphocytes.