Table 1. Summary of dysregulated miRNAs in cancer angiogenesis and metastasis.

Name	Expression	Tumor	Angiogenesis	Metastasis	Target gene	Reference
miR-29c	Down	Glioma	Suppression	Suppression	VEGF, MMP2	57
miR-195	Down	Hepatocellular carcinoma	Suppression	Suppression	VEGF, VAV2, CDC42	58
miR-199a-3p	Down	Hepatocellular carcinoma	Suppression	Suppression	VEGFA, VEGFR1, VEGFR2, HGF, MMP2	59
miR-497	Down	Hepatocellular carcinoma, breast cancer, pancreatic cancer	Suppression	Suppression	VEGFA, AEG-1, VEGFR2	60, 61, 62
miR-519c	Down	Lung adenocarcinoma, breast cancer	Suppression	Suppression	HIF-1alpha	63
miR-145	Down	Gastric cancer, neuroblastoma	Suppression	Suppression	HIF-2alpha, Ets1	64, 65
miR-107	Down	Colon cancer	Suppression	Suppression	HIF-1beta, VEGF, BDNF	67
miR-542-3p	Down	Breast cancer, hepatocellular carcinoma	Suppression	Suppression	ANG2	71, 72
miR-543	Down	Osteosarcoma, colorectal cancer	Suppression	Suppression	ANG2, KRAS, MTA1, HMGA2	73, 74
miR-9	Down	Neuroblastoma	Suppression	Suppression	MMP14	75
miR-181-5p	Down	Breast cancer, colon cancer	Suppression	Suppression	MMP14	76
miR-454	Down	Pancreatic cancer	Suppression	Suppression	LRP6	79
miR-126-3p	Down	Oral squamous cell carcinoma, hepatocellular carcinoma	Suppression	Suppression	VEGFA, LRP6, PIK3R2	80, 81
miR-26a	Down	Hepatocellular carcinoma	Suppression	Suppression	IL-6, HGF	83, 84
miR-451	Down	Osteosarcoma, hepatocellular carcinoma	Suppression	Suppression	IL-6R	85, 86
miR-34a	Down	Bladder cancer	Suppression	Suppression	CD44	88
miR-101	Down	Glioblastoma, nasopharygeal carcinoma	Suppression	Suppression	EZH2, ITGA3	89, 90
miR-124	Down	Bladder cancer, cervical cancer	Suppression	Suppression	UHRF1, AmotL1	91, 92
miR-135a	Down	Gastric cancer, non-small cell lung cancer	Suppression	Suppression	FAK, IGF-1	95, 96
miR-218	Down	Gastric cancer	Suppression	Suppression	ROBO1	99, 100
miR-320	Down	Oral squamous cell carcinoma, cholangiocarcinoma	Suppression	Suppression	Neuropilin 1	104, 105
miR-409-3p	Down	Fibrosarcoma	Suppression	Suppression	Angiogenin	108
miR-590-5p	Down	Colorectal cancer	Suppression	Suppression	NF90	112
miR-1301	Down	Hepatocellular carcinoma	Suppression	Suppression	BCL9	114
miR-93	Up	Breast cancer	Promotion	Promotion	Integrin-beta8, LATS2	120, 121
miR-378	Up	Non-small cell lung cancer	Promotion	Promotion	Sufu, Fus-1, HMOX1	125, 126
miR-155	Up	Breast cancer	Promotion	Promotion	VHL, C/EBPbeta	129, 131
miR-494	Up	Lung cancer	Promotion	Promotion	NOTCH1, PTEN	135, 136
miR-296	Up	Prostate cancer	Promotion	Promotion	HGS, ICAM1	139, 142
miR-1246	Up	Colorectal cancer	Promotion	Promotion	PML, CCNG2	145, 146
miR-181a	Up	Chondrosarcoma	Promotion	Promotion	RGS16	152
miR-221/222	Up	Thyroid carcinoma, glioma	Promotion	Promotion	ADIPOR1, TIMP2	153, 156