Plasma levels were calculated based on peripheral venous blood samples that were collected from indwelling catheters or by direct venipuncture into collection tubes. Baseline (Visit 2) and Day 28 (EOS) blood samples for ELND005 plasma levels were collected before dosing (time 0), and at 1.5 (±0.5), 3 (±0.5), and 4.5 (±0.5) hours after dosing. In addition, patients were encouraged to provide blood samples at 6 (±1) and 8 (±1) hours after dosing. At Day 14, one blood sample was collected (either before or after the first dose of study drug on Day 14).