Table 6.
Change from Baseline in NPI Total Scores for Participants with Baseline NPI Score ≥1 (n=15)
| Group | Participant | K-BIT IQ Score | Total NPI Score at Baseline | Total NPI Score at Week 4 | Change from Baseline |
|---|---|---|---|---|---|
|
| |||||
| Placebo | 001–001 | 48 | 1 | 1 | 0 |
| 002–003 | 68 | 5 | 9 | 4 | |
| 001–004 | 57 | 7 | 4 | −3 | |
|
| |||||
| ELND005 250 mg QD | 001–003 | 79 | 1 | 4 | 3 |
| 001–006 | 54 | 1 | 1 | 0 | |
| 001–008 | 40 | 1 | 1 | 0 | |
| 004–005 | 80 | 4 | 12 | 8 | |
|
| |||||
| ELND005 250 mg BID | 002–001 | 40 | 1 | 0 | −1 |
| 004–006 | 48 | 2 | 0 | −2 | |
| 001–002 | 79 | 3 | 6 | 3 | |
| 004–003 | 40 | 6 | 3 | −3 | |
| 004–004 | 40 | 12 | 0 | −12 | |
| 001–009 | 70 | 13 | 8 | −5 | |
| 001–011 | 40 | 14 | 3 | −11 | |
| 004–002 | 40 | 52 | 9 | −43 | |
BID = twice daily; K-BIT = Kaufman-Brief Intelligence Test; NPI = neuropsychiatric inventory; QD = once daily; Higher scores on the NPI indicate more behavioral disturbance.