Table 4a.

Results for various IPW and TMLE approaches in the plasmode simulation study (without truncation in the propensity score)

Approach	Outcome Model	Treatment Model	Estimate	SE	Bias	RMSE	Finite fitted values*
IPW1	A	NULL	−1.19	0.04	0.86	0.86	100%
IPW2	A	C1	−0.84	0.04	0.51	0.51	100%
IPW3	A	C2	−0.57	0.08	0.24	0.25	100%
IPW4	A	C3	−0.35	0.10	0.04	0.11	100%
TMLE1	A	NULL	−1.19	0.04	0.86	0.86	100%
TMLE2	A	C1	−0.84	0.04	0.51	0.51	100%
TMLE3	A	C2	−0.57	0.10	0.24	0.26	100%
TMLE4	A	C3	−0.31	0.30	0.02	0.31	97.2%
TMLE5	A,C1	NULL	−0.84	0.04	0.51	0.51	100%
TMLE6	A,C1	C1	−0.84	0.04	0.51	0.51	100%
TMLE7	A, C1	C2	−0.57	0.08	0.24	0.25	99.8%
TMLE8	A, C1	C3	−0.29	0.23	0.04	0.23	89.4%
TMLE9	A, C2	NULL	−0.58	0.05	0.25	0.26	100%
TMLE10	A, C2	C1	−0.58	0.05	0.25	0.25	100%
TMLE11	A,C2	C2	−0.56	0.07	0.23	0.24	100%
TMLE12	A, C2	C3	−0.31	0.12	0.03	0.12	96.8%
TMLE13	A, C3	NULL	−0.34	0.05	0.005	0.06	100%
TMLE14	A, C3	C1	−0.34	0.05	0.002	0.06	100%
TMLE15	A, C3	C2	−0.34	0.07	0.002	0.07	100%
TMLE16	A, C3	C3	−0.35	0.16	0.01	0.16	99%

^*Refers to settings in which the first step of the TMLE returned non-infinite predictions.