Table 1.

Factors involved in glucose sensing and metabolism and their role in virulence, when compared to the respective wild-type (WT) strain, in the human pathogenic fungi Aspergillus fumigatus, Cryptococcus neoformans and Candida albicans (NC = not characterized).

S.c protein	Role/function	A. fumigatus		C. neoformans		C. albicans
		Homolog	Virulence	Homolog	Virulence	Homolog	Virulence
Glucose sensing and uptake
Gpr1p	GPCR	GprC	Delayed (Gehrke et al., 2010)	Gpr1 (NC)	NC	Gpr1p	Context dependent (Miwa et al., 2004; Maidan et al., 2005b)
Gpr1p	GPCR	GprD	Attenuated (Gehrke et al., 2010)	-	-	-	-
-	GPCR	GprK	WT (wax moth larvae model; Jung et al., 2016)	-	-	-	-
Gpa2p	G protein	NC	NC	Gpa2	WT (Li et al., 2007)	Gpa2p	WT (Miwa et al., 2004)
Snf3p	Glucose sensor	NC	NC	Hsx1	Delayed (Liu et al., 2013)	Hgt4p	Delayed (Brown et al., 2006)
Rgt2p	Glucose sensor	NC	NC	Hsx2 (essential)	NC
Carbon catabolite repression
Mig1p	Transcriptional repressor of CCR	CreA	Attenuated (Beattie et al., 2017)	Mig1	WT (Caza et al., 2016)	Mig1p	WT (Zaragoza et al., 2000)
Tup1p	Co-repressor of CCR	Rco1	NC	Tup1	Delayed (Lee et al., 2009)	Tup1p	Avirulent (Murad et al., 2001)
Additional factors involved in CCR
Snf1p	Protein kinase	SnfA	NC	SnfA	Avirulent/delayed (Hu et al., 2008a; Yang et al., 2010)	Snf1p (Essential)	NC/Heterozygous mutant - WT (Petter et al., 1997)
Hxk2p	Hexokinase	HxkA/GlkA	NC	Hxk1/Hxk2	Avirulent -double mutant only (Price et al., 2011)	Hxk2p	NC
-	De-ubiquitination enzyme	CreB	NC	-	-	Ubp13p	NC
-	WD-40 repeat protein	CreC	NC	-	-	Cop1p (C3_01720C_A)	NC
-	Arrestin	CreD	NC	-	-	Rod1p	NC