Figure 2.

Polygenic Risk Scores and Estimates of Statistical Power for AF-Associated Loci

(A) Polygenic risk scores stratified by age of disease onset. White dots represent medians, black boxes represent interquartile ranges, black whiskers represent 1.5× the interquartile range, and colored areas show the probability density of the data. The vertical gray dotted line represents the median score for control individuals.

(B) Statistical-power estimates stratified by age of disease onset. The upper panel shows the necessary statistical power to detect risk loci (each represented by a dot) on the basis of the observed allele frequencies within subgroups, the number of case (bottom panel) and control (n = 61,607) individuals, and α = 5 × 10⁻⁸.