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Table 2. Mean and standard deviation of average of 24-hour ambulatory systolic and diastolic blood pressures before and after treatment.

Characteristics Placebo group (n = 20) Spironolactone group (n = 20) Treatment difference p-value
Baseline 1 months Baseline 1 months
Blood pressure indices
 Systolic blood pressure (mmHg) 143.70 ± 9.31 141.05 ± 9.64 143.55 ± 8.23 137.10 ± 7.57 -4.5 < 0.001
 Diastolic blood pressure (mmHg) 85.55 ± 7.44 83.60 ± 5.74 89.50 ± 4.69 87.15 ± 4.69 -1.3 0.099
Subgroups based on potassium level
 SBP in patients with K ≥ 4.2 146.87 ± 7.98 144.25 ± 8.27 142.91 ± 8.25 137.16 ± 7.45 -4.95 < 0.001
 SBP in patients with K < 4.2 141.55 ± 9.85 138.91 ± 10.2 144.55 ± 8.66 137.00 ± 8.26 -3.7 0.016
 DBP in patients with K ≥ 4.2 89.50 ± 6.78 85.37 ± 6.34 89.83 ± 4.91 86.33 ± 4.49 -2.37 0.014
 DBP in patients with K < 4.2 82.91 ± 6.89 82.41 ± 5.24 89.00 ± 6.69 88.37 ± 5.01 0.87 0.295
 SBP in patients with K ≥ 4.0 146.50 ± 6.77 143.75 ± 6.86 144.23 ± 9.21 137.05 ± 7.85 -5.14 < 0.001
 SBP in patients with K < 4.0 139.50 ± 11.3 137.00 ± 12.1 142.28 ± 6.47 135.28 ± 7.22 -3.28 0.078
 DBP in patients with K ≥ 4.0 87.66 ± 6.38 85.08 ± 5.43 90.46 ± 5.22 86.84 ± 4.68 -2.96 0.001
 DBP in patients with K < 4.0 82.37 ± 8.19 81.37 ± 5.80 87.71 ± 6.07 87.71 ± 5.02 1.78 0.058

DBP, diastolic blood pressure; SBP, systolic blood pressure.