Table 2. Mean and standard deviation of average of 24-hour ambulatory systolic and diastolic blood pressures before and after treatment.
Characteristics | Placebo group (n = 20) | Spironolactone group (n = 20) | Treatment difference | p-value | ||
Baseline | 1 months | Baseline | 1 months | |||
Blood pressure indices | ||||||
Systolic blood pressure (mmHg) | 143.70 ± 9.31 | 141.05 ± 9.64 | 143.55 ± 8.23 | 137.10 ± 7.57 | -4.5 | < 0.001 |
Diastolic blood pressure (mmHg) | 85.55 ± 7.44 | 83.60 ± 5.74 | 89.50 ± 4.69 | 87.15 ± 4.69 | -1.3 | 0.099 |
Subgroups based on potassium level | ||||||
SBP in patients with K ≥ 4.2 | 146.87 ± 7.98 | 144.25 ± 8.27 | 142.91 ± 8.25 | 137.16 ± 7.45 | -4.95 | < 0.001 |
SBP in patients with K < 4.2 | 141.55 ± 9.85 | 138.91 ± 10.2 | 144.55 ± 8.66 | 137.00 ± 8.26 | -3.7 | 0.016 |
DBP in patients with K ≥ 4.2 | 89.50 ± 6.78 | 85.37 ± 6.34 | 89.83 ± 4.91 | 86.33 ± 4.49 | -2.37 | 0.014 |
DBP in patients with K < 4.2 | 82.91 ± 6.89 | 82.41 ± 5.24 | 89.00 ± 6.69 | 88.37 ± 5.01 | 0.87 | 0.295 |
SBP in patients with K ≥ 4.0 | 146.50 ± 6.77 | 143.75 ± 6.86 | 144.23 ± 9.21 | 137.05 ± 7.85 | -5.14 | < 0.001 |
SBP in patients with K < 4.0 | 139.50 ± 11.3 | 137.00 ± 12.1 | 142.28 ± 6.47 | 135.28 ± 7.22 | -3.28 | 0.078 |
DBP in patients with K ≥ 4.0 | 87.66 ± 6.38 | 85.08 ± 5.43 | 90.46 ± 5.22 | 86.84 ± 4.68 | -2.96 | 0.001 |
DBP in patients with K < 4.0 | 82.37 ± 8.19 | 81.37 ± 5.80 | 87.71 ± 6.07 | 87.71 ± 5.02 | 1.78 | 0.058 |
DBP, diastolic blood pressure; SBP, systolic blood pressure.