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. 2017 Apr 19;9(1):15–32. doi: 10.1007/s13238-017-0408-4

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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A typical TMDD graph exhibiting the relationship between clearance or t_1/2 and mAb dose. Anti-α_v mAb was infused to cancer patients; clearance or terminal half-life (t_1/2) was plotted against dose (0.1, 0.3, 1, 3, and 10 mg/kg). Adapted from Mullamitha et al., Clin Cancer Res. (2007)